Puff City Clinic
PI: Mei Lu, PhD
Asthma continues to be a major public health problem in the US with high economic and social costs. Vulnerable ethnic communities are disproportionately affected by asthma as demonstrated by higher morbidity and mortality for these groups. These disparities are especially true in urban teens. We have completed two school-based, randomized trials of a web-based, computer-tailored asthma management intervention that targets urban teens (Puff City). Results showed reductions in self report of symptoms and activity limitations. Puff City has not yet been evaluated as a clinical tool or one that is initiated in a clinical setting. The current paradigm for conducting such a trial is costly with respect to patient recruitment, intervention delivery, and data collection and management.Electronic initiatives such as remote data capture (RDC) for data collection and utilization of patient electronic medical records (EMR) are revolutionizing the conduct of clinical trials. Comparative effectiveness methods (CEMs), adaptive designs and pragmatic trials, are recommended to enhance trial efficiency and to study real-world effectiveness. The objective of this proposal is 1) to implement a seamless clinical trial lifecycle through electronic initiatives and ii) to design and conduct an phase II/III randomization trial using both CEMs and EMR-RDC integration to evaluate Puff City in teens in a clinical setting. (08/15/2012 - 05/31/2014)

